Plasmid

noun (countable)
/ˈplæzmɪd/
A plasmid is a small, circular, double-stranded DNA molecule found in bacteria (and some eukaryotes) that replicates independently of the chromosomal DNA and typically carries accessory genes, such as those conferring antibiotic resistance. Plasmids are central to genetic engineering as vectors for introducing foreign DNA into host cells, enabling the production of recombinant proteins such as human insulin. The horizontal transfer of antibiotic-resistance plasmids among bacteria is a primary driver of antimicrobial resistance (AMR), which the WHO has identified as a global health emergency; India's National Action Plan on AMR (2017–2021) targeted this mechanism.

✍️ Usage in a UPSC answer

The horizontal transfer of plasmids carrying carbapenem-resistance genes among Klebsiella pneumoniae strains in Indian tertiary-care hospitals has created clinical scenarios where patients are infected with bacteria resistant to virtually all available antibiotics.

Synonyms

extrachromosomal DNAepisome (partially synonymous)mobile genetic elementresistance plasmid (when carrying resistance genes)

Antonyms

chromosomal DNAnuclear genomeintegrated DNA

🌱 Word Family

plasmid vector (noun phrase), plasmidic (adjective, rare), megaplasmid (noun), minicircle (partial synonym)

🔡 Root

Greek plasma = something moulded or formed (from plassein = to mould) + -id (small entity suffix)

📜 Etymology

The term was coined by American molecular biologist Joshua Lederberg in 1952 from Greek plasma (something moulded, from plassein = to mould or shape) with the diminutive suffix -id, denoting a small entity. Lederberg used the term to describe any extrachromosomal genetic element, though its usage has since narrowed to circular extrachromosomal DNA in bacteria. Lederberg shared the 1958 Nobel Prize in Physiology or Medicine for discoveries in bacterial genetics.

🧠 Memory Hook

A plasmid is a 'mini moulded thing' (plasma = moulded + -id = small) — imagine a tiny circular ring of DNA that bacteria carry around like a spare tool belt. While the chromosome is the main blueprint, the plasmid is the small, handy extra toolkit bacteria can share with each other.

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